How Suboxone Film Works in Your Body
If you’re considering or using Suboxone film for opioid use disorder, understanding its side effects is crucial. This guide explains what to expect.
Here’s a quick look at the most common and serious side effects:
Common Suboxone Film Side Effects:
- Headache
- Nausea and Vomiting
- Constipation
- Sweating
- Insomnia
- Dizziness
Serious Suboxone Film Side Effects:
- Respiratory depression (severe trouble breathing)
- Liver damage
- Adrenal insufficiency (hormone problems)
- Severe allergic reactions
- Serious dental issues, including tooth decay
Suboxone film is a vital tool in treating opioid use disorder, but like all medicines, it has potential side effects. Knowing what to expect helps you manage your treatment safely.
As the Founder and Medical Director of National Addiction Specialists, I’m Chad Elkin. I’ve helped many patients minimize suboxone film side effects. My goal is to provide clear information so you can make informed health decisions. Let’s explore how Suboxone film works.

Suboxone film is a key medication-assisted treatment (MAT) for opioid use disorder. It combines two active ingredients, buprenorphine and naloxone, which work together to help you recover.
Buprenorphine, a partial opioid agonist, attaches to the brain’s opioid receptors but with a weaker effect than full opioids. This action reduces cravings and withdrawal symptoms without causing a strong high, stabilizing your brain for a smoother recovery. For more details, see our guide on how buprenorphine works.
Naloxone is an opioid antagonist included to deter misuse. If the film is injected, naloxone activates and causes immediate, severe withdrawal symptoms, discouraging improper use.
Together, these ingredients work on the central nervous system to prevent withdrawal and cravings. This medication is a powerful tool for managing dependence and regaining control. Learn more about the [Benefits of Suboxone Treatment] and how it helps with withdrawal in our guide: [Does Suboxone Help with Withdrawal Symptoms?].
How to Take Suboxone Film Correctly
Proper administration is vital for Suboxone film to work as intended and to minimize potential suboxone film side effects. The film is designed for sublingual administration (under the tongue).
Here’s how to take it:
- Prepare: Wash your hands and moisten your mouth with water to help the film dissolve.
- Place: Put the film flat under your tongue. If using multiple strips, place them on opposite sides.
- Dissolve: Let the film dissolve completely (5-10 minutes). Do not chew, swallow, or move it to ensure effectiveness.
- Wait: Avoid eating, drinking, smoking, or talking for 15-20 minutes to allow for full absorption.
- Rinse: After it dissolves, swish with water and swallow to protect your dental health from the film’s acidity.

Following these steps ensures you receive the full benefit of your suboxone treatment and helps mitigate oral side effects. For more comprehensive information, we encourage you to read our guide: [More info on Suboxone treatment options].
How is Suboxone Film Different from Other Forms?
Suboxone comes in various forms, but the film is a common choice. The main difference from tablets lies in its delivery method and composition.
- Rapid Absorption: The film dissolves under the tongue for quick, direct absorption into the bloodstream, bypassing the digestive system for a consistent dose.
- Acidity: The film is acidic to aid absorption, but this can lead to dental problems over time, a key difference from some tablets.
- Misuse Deterrence: Like tablets, the film contains naloxone to deter misuse. Its form may be perceived as harder to misuse than crushable tablets.
- Convenience: Individually packaged films are discreet and easy to carry, simplifying daily treatment management.
Understanding these differences helps us tailor treatment plans to individual needs. For a deeper dive into how Suboxone compares to other buprenorphine medications, check out: [Suboxone vs. Subutex].
A Closer Look at Suboxone Film Side Effects
When starting Suboxone, understand the potential suboxone film side effects. Most are mild and temporary, fading as your body adjusts. However, distinguish between normal adjustments and symptoms that need immediate attention.
We encourage honest conversations about how you’re feeling. If a side effect becomes severe or persistent, please reach out to your treatment team immediately. You can also report side effects to the FDA through its MedWatch program to help improve medication safety for everyone.
Common Side Effects
Your body needs time to adjust to Suboxone film. Based on clinical trials, here are the most common suboxone film side effects:
- Headaches: The most common side effect (36% of users), these are often mild and improve with time, hydration, and rest.
- Nausea and vomiting: Often occurs in the first few weeks. Taking your dose consistently and eating small meals can help.
- Constipation: Affecting 12% of users, this is due to buprenorphine slowing digestion. Increase water, fiber, and activity to manage it.
- Sweating: Experienced by 14% of patients, this usually lessens over time.
- Insomnia: Affecting 14% of users, this can be managed with good sleep hygiene, like a consistent bedtime routine and avoiding caffeine.
- Dizziness: You may feel unsteady, but this typically improves as your body adjusts.
For a complete guide on managing these symptoms, check out: [What to Expect: Suboxone Side Effects].
Serious Side Effects
While less common, some suboxone film side effects are serious and require immediate medical attention.
- Respiratory depression: This is dangerously slow or shallow breathing and can be life-threatening. The risk is highest when mixing Suboxone with alcohol, benzodiazepines, or other depressants. If you see signs of extreme drowsiness or slow breathing, call 911. For more information, read: [Dangers of Mixing Suboxone and Alcohol].
- Adrenal insufficiency: This hormonal issue can cause extreme fatigue, weakness, dizziness, and persistent muscle or joint pain.
- Liver damage: This is rare but serious. Symptoms include yellowing skin or eyes (jaundice), dark urine, and severe stomach pain. Regular blood tests are important for monitoring.
- Severe allergic reactions: Signs include rash, hives, swelling of the face or throat, or difficulty breathing. This is a medical emergency requiring an immediate 911 call.
- Dependence and overdose risk: Suboxone contains an opioid, so physical dependence will develop. Stopping requires medical supervision. Misuse, especially by injection or with other substances, can lead to a fatal overdose. Learn more about these risks: [Overdosing on Suboxone].
The naloxone in Suboxone helps prevent misuse, but it’s not foolproof. If you suspect an overdose, call 911 immediately.
The Link Between Suboxone Film and Dental Problems
A significant and concerning suboxone film side effect is its impact on dental health. This is a serious risk that all patients using the sublingual film should be aware of.

The dental problems are caused by the film’s acidity. When placed under the tongue, the acidic film sits against your teeth as it dissolves. This repeated exposure can erode tooth enamel, the protective outer layer of your teeth.
Suboxone also causes dry mouth (xerostomia), which worsens the problem. Saliva is your mouth’s natural defense, neutralizing acid and washing away bacteria. With reduced saliva, the acid from the film remains, creating an environment where tooth decay thrives. Studies show over 90% of users have saliva that can’t effectively buffer this acid.
Research and FDA Action on Dental Health
This link is supported by significant research. A December 2022 JAMA study on dental outcomes confirmed that users of sublingual buprenorphine have a much higher risk of severe dental issues like cavities and tooth loss. In response to this and hundreds of patient reports, the FDA issued an official warning in January 2022. Subsequently, the manufacturer, Indivior, updated Suboxone’s warning label to include these dental risks.
Signs of Tooth Decay to Watch For
Being on Suboxone film means you need to be vigilant about your dental health. Catching problems early is key to preventing serious damage. Watch for these signs:
- Tooth sensitivity to hot, cold, or sweet items.
- Visible cavities like dark spots, holes, or pits on teeth.
- Gum inflammation, such as red, swollen, or bleeding gums.
- Persistent pain or aching, especially when chewing.
- Tooth discoloration or a dull, yellowed appearance.
- Persistent bad breath, even after brushing.
- Cracked or fractured teeth as enamel weakens.
If you experience any of these symptoms, contact your dentist right away and inform them that you are taking Suboxone film.
How to Prevent Tooth Decay While Using Suboxone
The good news is that you can take action to protect your teeth. With the right preventive care, you can significantly reduce your risk of serious dental problems.
- Rinse immediately: After the film dissolves, rinse your mouth with water and swallow to wash away acid.
- Wait to brush: Wait at least one hour after your dose before brushing your teeth to avoid scrubbing away softened enamel.
- Regular dental checkups: See your dentist every six months and inform them you use Suboxone film.
- Use fluoride: Use fluoride toothpaste and an alcohol-free fluoride mouthwash daily to strengthen enamel.
- Combat dry mouth: Chew sugar-free gum and stay well-hydrated to stimulate saliva production.
Suboxone Withdrawal and Long-Term Use
Suboxone is designed for long-term treatment, which leads to physical dependence. Dependence is not addiction. It means your body has adapted to the medication to function normally, similar to needing daily blood pressure medicine. This is an expected part of the treatment that keeps you stable in recovery.
Never stop Suboxone abruptly. Doing so can cause prolonged withdrawal symptoms. A safe exit from treatment requires a gradual dose reduction, or tapering, under medical supervision.
Treatment duration varies, but for many, it’s a long-term commitment that provides stability and prevents relapse. The benefits of sustained recovery often outweigh concerns about long-term medication use. Learn more in our guide to the [Long-Term Effects of Suboxone Use].
Suboxone’s withdrawal timeline is unique. Due to buprenorphine’s long half-life, symptoms are often milder but more prolonged than with other opioids. Psychological effects like anxiety and cravings can be significant. See our detailed guide: [From Start to Finish: Understanding the Suboxone Withdrawal Timeline].
Common Withdrawal Symptoms
When tapering off Suboxone too quickly or stopping suddenly, you may experience a range of symptoms. These are best managed with professional guidance from a Suboxone Withdrawal Treatment provider.
- Physical symptoms: Muscle aches, joint pain, nausea, vomiting, diarrhea, runny nose, watery eyes, and goosebumps.
- Psychological symptoms: Intense anxiety, restlessness, insomnia, and powerful cravings for opioids.
Managing Long-Term Treatment
Successful long-term treatment is about more than just medication. A comprehensive approach is key.
- Counseling and behavioral therapy: While Suboxone stabilizes your brain, therapy addresses the root causes of addiction.
- Regular medical check-ins: These are vital for monitoring your progress, managing suboxone film side effects, and adjusting your dose.
- Strong support systems: Recovery is easier with support from family, friends, or groups.
National Addiction Specialists provides personalized Suboxone Treatment Programs that combine these elements. Our confidential telemedicine services are available in Tennessee and Virginia, and we accept Medicaid and Medicare to ensure care is accessible.
Make an Appointment to Treat Addiction
Please don’t hesitate. Make an appointment today.
https://www.nationaladdictionsspecialists.com/new-patient-packet/
Frequently Asked Questions about Suboxone Film Side Effects
It’s natural to have questions about suboxone film side effects. Here are answers to some of the most common concerns we hear from patients.
What should I do if I experience serious side effects?
If you experience serious side effects like trouble breathing, severe dizziness, or signs of liver problems (yellow skin/eyes, dark urine), call 911 immediately. The same applies to severe allergic reactions (facial/throat swelling, hives).
For less severe but concerning side effects, contact your provider. We can adjust your treatment or offer management strategies. You can also report side effects to the FDA’s MedWatch program. Please don’t hesitate to call us; we want to help.
Can Suboxone film cause weight changes?
While not a primary side effect in clinical trials, some patients report weight changes. Recovery involves many lifestyle shifts that can affect weight, such as changes in diet, stress, and activity levels. If you have concerns about weight changes, discuss them with your provider. We can assess your overall health and find strategies that work for you.
How long do the side effects of Suboxone film last?
The duration of side effects varies. Common initial side effects like headaches and nausea typically improve within a few days to weeks as your body adjusts. Other issues, like dental problems, require ongoing management. Serious but rare side effects may need long-term care. Regular communication with your healthcare team is key to managing any symptoms that arise. Contact us if anything feels wrong.
Take Control of Your Recovery Journey
While understanding suboxone film side effects is important, don’t let it discourage you. Suboxone film is a highly effective treatment for opioid use disorder, and its side effects are manageable with proper medical supervision.
Personalized treatment is key, as every patient’s journey is unique. At National Addiction Specialists, we take your concerns about side effects seriously. Our expert providers offer more than just a prescription; we provide comprehensive support to ensure your treatment is both comfortable and effective. Through our confidential telemedicine services, we help patients in Tennessee and Virginia manage everything from common side effects to specific concerns like dental health. We accept Medicaid and Medicare because quality care should be accessible to all.
Recovery is a journey, and you don’t have to walk it alone. We are here to support you every step of the way.
Make an Appointment to Treat Addiction
Please don’t hesitate. Make an appointment today.
https://www.nationaladdictionsspecialists.com/new-patient-packet/


